Gamma Delta T cells and their role in the APR to IV ABP v2.2

• Research type

  Research Study

• Full title

  Gamma Delta T cells and their role in the acute phase reaction to intravenous bisphosphonates

• IRAS ID

  15255

• Contact name

  AK Sewell

• Sponsor organisation

  Cardiff University

• Eudract number

  2007-005647-14

• ISRCTN Number

  1

• Research summary

  We intend to perform an observational study of patients who attend our bone treatment unit to have intravenous bisphosphonate treatment for either osteoporosis or Paget??s disease of bone. We will be studying the activity of the patient's peripheral white blood cells, in particular the activity of the Gamma Delta T cells, and reviewing their quality of life. Blood samples will be taken immediately prior to treatment, 24 hours after treatment, 72 hours after treatment and 14 days after treatment from patients who are receiving their first infusions of intravenous bisphosphonate. The participants will be asked to record any symptoms they have following their treatment. When the participants attend for the blood sampling they will be asked to complete a simple questionnaire to measure quality of life. We are investigating whether there is a relationship between the activity of Gamma Delta T cells and the acute phase reaction which can occur after a first dose of intravenous bisphosphonate.

• REC name

  Wales REC 2

• REC reference

  09/WSE02/14

• Date of REC Opinion

  16 Mar 2009

• REC opinion

  Further Information Favourable Opinion