Frozen Embryo Transfer Progesterone Levels (v1)
Research type
Research Study
Full title
Correlation between mean serum progesterone levels on the day of frozen embryo transfer (FER) with ongoing pregnancy rates: Prospective, analytical observational cohort study .
IRAS ID
259960
Contact name
Garima Srivastava
Contact email
Sponsor organisation
Homerton university Hospital NHS Foundation trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Much work has been done in IVF regarding stimulation. However, not much attention has been paid to the pregnancy support medications. This is particularly true for looking at the co-relation between pregnancy support medication and serum progesterone levels in frozen embryo transfers. Although all the formulations available for the pregnancy support have been claimed to result in similar pregnancy rates,recently there has been a keen interest whether the blood progesterone levels differ in individual subjects after these medications. Also, should there be an effort for personalised protocols rather than a standardised regime for all for improving pregnancy rates based on blood progesterone levels?
This study aims at finding a correlation between blood progesterone levels on the day of Frozen Embryo transfer (FER) and ongoing pregnancy rates after using standard treatment protocols.
Women fulfilling the eligibility criteria between March 2019 to December 2019 for the study are going to be prepared with the standard hormone replacement therapy (HRT) with estradiol valreate(8mgs once a day) and natural progesterone pessaries(400mgs, threetimes a day) for FER cycle at Homerton Fertility Centre. Blood progesterone levels will be taken on the day of FER which is after 5 days of progesterone supplementation.Patients are going to be followed till 20 weeks of pregnancy or till the pregnancy test is negative.
The blood progesterone levels will be correlated to the ongoing pregnency rates, clinical pregnancy rate, miscarriage rate and biochemical pregnancy rate.REC name
London - Bromley Research Ethics Committee
REC reference
19/LO/0310
Date of REC Opinion
6 Mar 2019
REC opinion
Favourable Opinion