Formation of chlorinated disinfection by-products
Research type
Research Study
Full title
The effect of irrigation with sodium hypochlorite on the formation of chlorinated disinfection by-products (DBPs) in the root canal system and periradicular space during instrumentation.
IRAS ID
152590
Contact name
Francesco Mannocci
Contact email
Clinicaltrials.gov Identifier
N/A, N/A
Research summary
Sodium hypochlorite has been widely used in endodontics as gold standard for the irrigation of the inflamed or infected root canal system. The application of sodium hypochlorite promotes a wide range of chemical interactions with the multivariable content of the root canal system. The identity of the content is a mixture of disintegrated necrotic pulp tissue, bacterias, irrigants, infected or non-infected dentine debris and tissue fluids, which are representative of the formed smear layer during instrumentation. Sodium hypochlorite definitely decomposes organic tissue components, co-reacts with inorganic components and at the same time its concentrated active chlorine species are reduced. An increasing amount of published research data from water, environment and chemistry research domains is available in literature with regard to the potential of chlorinated solutions to form several by-products during chlorination/disinfection procedures in water supply systems, drinking water, swimming pools and raw water environments. Several emerging chlorinated disinfection by-products (DBPs) are potentially mutagenic, carcinogenic and may pose adverse effects in general health. After a thorough review in dental literature, it was concluded that there are no available reports upon the potential generation of disinfection by-products (DBPs) when sodium hypochlorite is used for the chemomechanical preparation of root canals. The identification and the impact of formed DBPs in the root canal system and in the periradicular space has not been elucidated yet. This project will investigate the identification and quantification of any emerging chlorinated DBPs and will consist 2 phases.
1. Phase 1: Assessment of the probability and factors promoting the occurrence of chlorinated disinfection by-products.
2. Phase 2: Transmittance of previous knowledge in laboratory conditions in the field of endodontics (study model-extracted teeth-development of periradicular environment, chemomechanical preparations of root canals).REC name
Wales REC 4
REC reference
14/WA/1004
Date of REC Opinion
6 Jun 2014
REC opinion
Further Information Favourable Opinion