Food Protein Induced Enterocolitis Syndrome (FPIES)
Research type
Research Study
Full title
British Paediatric Surveillance Study of Food Protein Induced Enterocolitis Syndrome (FPIES) presenting to Paediatricians in the UK and Republic of Ireland
IRAS ID
237585
Contact name
Gary Hylton Stiefel
Contact email
Sponsor organisation
University Hospitals of Leicester NHS Trust
Duration of Study in the UK
1 years, 1 months, 1 days
Research summary
Food Protein Induced Enterocolitis Syndrome (FPIES – pronounced effpies) is a delayed type of food allergy in infants, which leads to repeated vomiting and other gut symptoms several hours after a trigger food (or baby formula) is eaten. It can lead to rapid dehydration and shock.
Delays in diagnosis are frequent, since many front-line healthcare providers are not aware of the condition, and presenting clinical features can mimic more common presentations: such as septic shock and surgical abdominal emergencies. Consequently, children with FPIES often have several episodes, additional investigations and hospital admissions before the diagnosis is made. There are only a handful or reports of children with FPIES in the UK.
This study is intended to improve our knowledge of the incidence, clinical presentation and management of FPIES in the UK and Ireland. It will use the British Paediatric Surveillance Unit (BPSU): a well-established research network for rare diseases. In consequence, it will raise the profile of FPIES and improve awareness among paediatricians. The BPSU will survey all consultant paediatricians every month for 13 months and ask them to report new cases of FPIES to their central reporting system. We will then ask the reporting doctor for further information about the case by questionnaire. Patients will not be contacted for this study.
REC name
London - Stanmore Research Ethics Committee
REC reference
18/LO/0972
Date of REC Opinion
20 Jun 2018
REC opinion
Favourable Opinion