Fluid Monitor, Version 1
Research type
Research Study
Full title
Monitoring Fluid Balance in Response to GLP-1 receptor activation in Healthy Volunteers
IRAS ID
322292
Contact name
David Murphy
Contact email
Sponsor organisation
Bristol University
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
A part of the brain called the hypothalamus, specifically a region called the supraoptic nucleus, makes and releases the hormones vasopressin and oxytocin. These hormones regulate fluid balance and are of great importance for survival. In addition, scientists are becoming increasingly aware of the wider role of these hormones such as in the development of Type 2 diabetes and kidney failure. Therefore, it is very important to fully understand how they are regulated. For example, one of the other hormones affecting vasopressin and oxytocin release is called GLP-1 which is produced by gut cells in response to food intake, but also in the brain. There is a dearth in our knowledge regarding the effects of GLP-1 on vasopressin and oxytocin release in humans. We aim to develop methods for studying the release of vasopressin and oxytocin in humans in the steady state and in response to influences such as GLP-1. We will use drug called Liraglutide (widely used in the routine clinical practice for the treatment of diabetes and weight management) that acts in the same way as GLP-1. We hope that we will be able to understand vasopressin and oxytocin system better, particularly its involvement in the development of other diseases such as diabetes.
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
23/NW/0106
Date of REC Opinion
16 May 2023
REC opinion
Further Information Favourable Opinion