FLOW_CD
Research type
Research Study
Full title
Evaluation of Intestinal lymphocytes and Interleukin Levels by Flow Cytometry in Coeliac Disease
IRAS ID
336240
Contact name
Hugo Penny
Contact email
Sponsor organisation
Sheffield Teaching Hospitals NHS FT
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Coeliac disease is diagnosed by taking blood samples and biopsies from the small intestines. People need to have consumed gluten in their diet for 6 weeks before these tests to ensure that the changes characteristic of coeliac disease are identifiable. This can lead to distress as gluten typically causes symptoms in these patients. Evidence suggests that analysis of protein levels (interleukins) in the blood, and/or immune cells (intraepithelial lymphocytes (IELs)) in the biopsies of patients, is an alternative way to diagnose coeliac disease irrespective of whether the patient has been consuming gluten. This study aims to evaluate this strategy and in doing so hopes to shed new light on new ways to diagnose this condition which may be more acceptable to patients.
REC name
Wales REC 3
REC reference
23/WA/0347
Date of REC Opinion
18 Jan 2024
REC opinion
Further Information Favourable Opinion