Flash glucose measurement in patients on total parenteral nutrition
Research type
Research Study
Full title
What happens to frequently measured glucose levels in patients, both with and without diabetes, who are receiving total parenteral nutrition (TPN).
IRAS ID
254046
Contact name
Michael Mansfield
Contact email
Sponsor organisation
Leeds Teaching Hospitals
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
0 years, 9 months, 30 days
Research summary
Intravenous nutrition is a means of providing all the nutritional requirements of people who have severe small bowel disease, usually with extensive small bowel resection. Some patients require longer term IV nutrition, usually 10-12 hours per day and given overnight at home. At least 10% of people on longer term IV nutrition also have diabetes. Intravenous nutrition includes glucose delivered directly in to the large veins. Unsurprisingly this causes elevated blood glucose levels, particularly in people with diabetes, and with a time profile that is very different from that seen after eating in the normal way. This can make treatment of hyperglycaemia more challenging and there are no local or national guidelines.
Flash glucose monitoring (FreeStyle Libre) is increasingly used in diabetes practice. It measures glucose in fat tissue every few minutes (this very closely correlates with blood glucose). It is very simple to fit, patients can do it themselves and lasts 2 weeks. As a result this study aims to use the FreeStyle Libre device to investigate and so describe what happens to glucose levels in patients receiving IV nutrition across day and night in detail. We will look at this trend in 5 patients with diabetes and 5 patients without diabetes receiving TPN.
REC name
East of England - Cambridge East Research Ethics Committee
REC reference
18/EE/0409
Date of REC Opinion
6 Feb 2019
REC opinion
Further Information Favourable Opinion