FLAIR* to differentiate between MS and cerebral small vessel disease
Research type
Research Study
Full title
FLAIR* to differentiate between multiple sclerosis and cerebral small vessel disease
IRAS ID
127551
Contact name
Klaus Schmierer
Contact email
Sponsor organisation
Barts Health NHS Trust
Duration of Study in the UK
0 years, 6 months, 1 days
Research summary
Multiple sclerosis (MS) is a common and disabling brain condition. Magnetic resonance imaging (MRI) is not only the most important tool to aid the diagnosis of MS but is also crucial for decisions about treatment.
A common problem is the uncertainty whether lesions in the brain seen on MRI are caused by MS or by a different aetiology such as cerebral small vessel disease (CSVD), which is a condition associated with ageing and arterial hypertension.In this study we will test whether it is feasible, using MRI, to distinguish MS from CSVD. For this purpose we will employ a novel post-processing algorithm called FLAIR*.
A group of volunteers with CSVD will be imaged using MRI and the Flair* technique. The images will be processed and compared to the imaging of patient's with MS.
Distinguishing the conditions has already been possible in more advanced MRI scanners, that are used in research. The ability to distinguish between these diseases has not been shown with the MRI scanners available in normal clinical practice.
The technique would allow earlier and more confident diagnosis of MS. Some of the treatments for MS have significant side effects or risks, and are only used when a firm diagnosis is established. These treatments are monitored to ensure the disease is controlled. The new MRI technique would allow earlier and more appropriate treatment.
REC name
North West - Haydock Research Ethics Committee
REC reference
15/NW/0065
Date of REC Opinion
14 Jan 2015
REC opinion
Favourable Opinion