FerTZI, FERTilisation rates predicted by TeratoZoospermia Index 1
Research type
Research Study
Full title
Teratozoospermia Index (TZI) as a predictor of fertilisation rates in IVF using sperm prepared from density gradient centrifugation (DGC).
IRAS ID
325355
Contact name
Jason Kasraie
Contact email
Sponsor organisation
Shrewsbury and Telford Hospital NHS Trust
Duration of Study in the UK
0 years, 6 months, 2 days
Research summary
The shape of the sperm (morphology) is examined as part of a sperm test to check for issues with a man’s sperm. When looking at sperm morphology, we cannot tell whether sperm are working normally. A calculation known as the Teratozoospermia Index (TZI) may be able to predict how likely it is that the sperm can fertilise (fuse with) the egg. \n\nDuring In-Vitro Fertilisation (IVF) treatment, sperm must be prepared before mixing with the eggs. The sperm preparation method is called density gradient centrifugation (DGC). DGC filters out most of the abnormal/dead sperm.\n\nThe purpose of this project is to see if sperm prepared for treatment with fewer abnormalities have a higher chance of fertilising the egg. This will be done by taking small volumes of sperm on the day of treatment before and after it has been prepared. The sperm will be examined under the microscope and the TZI will be calculated. These results will be compared to the number of eggs fertilised. It is expected that if less abnormalities are present on the sperm, then more eggs will fertilise. If so, this will show that TZI is helpful to predict whether the sperm will fertilise an egg.\n
REC name
South Central - Oxford B Research Ethics Committee
REC reference
23/SC/0165
Date of REC Opinion
19 May 2023
REC opinion
Further Information Favourable Opinion