Feasibility Study - fMRI in measuring the effect of HD on the Brain
Research type
Research Study
Full title
A Feasibility study to explore the role of functional Magnetic Resonance Imaging (fMRI) in measuring the effect of haemodialysis (HD) on cerebral blood flow and function.
IRAS ID
140259
Contact name
Colin Jones
Contact email
Sponsor organisation
York Teaching Hospital NHS Foundation Trust
Research summary
Patients with end stage kidney failure need regular dialysis treatment to sustain their life. During haemodialysis excess water and salt are removed from the body, this can mean large volumes of fluid are removed over short periods of time. Some patients experience side effects of large amounts of fluid removal, in more severe cases falls in blood pressure can lead to decreased vital organ perfusion, resulting in decreased conscious level and heart problems. Falls in blood pressure during dialysis and postural falls in systolic blood pressure immediately after dialysis have been identified as significant predictors of increased mortality in dialysis patients. While dialysis associated hypotension may lead to a reduction in cerebral blood flow, no direct evidence links intradialytic hypotension with increased cerebrovascular mortality. The proposed study will seek to bridge this gap in knowledge by investigating the effects of a single haemodialysis treatment on cerebral blood flow and function in stable patientsundergoing regular outpatient haemodialysis.
REC name
Yorkshire & The Humber - Leeds West Research Ethics Committee
REC reference
14/YH/0107
Date of REC Opinion
28 May 2014
REC opinion
Further Information Favourable Opinion