FAST III Trial

• Research type

  Research Study

• Full title

  Fractional Flow Reserve or 3D-Quantitative-Coronary-Angiography Based Vessel-FFR guided revascularization

• IRAS ID

  305508

• Contact name

  Adrian Banning

• Contact email

  adrian.banning@ouh.nhs.uk

• Sponsor organisation

  European Cardiovascular Research Institute (ECRI)

• Clinicaltrials.gov Identifier

  NCT04931771

• Duration of Study in the UK

  2 years, 2 months, 28 days

• Research summary

  The study is being conducted in patients exhibiting obstruction in one or more of the vessels that supply the heart with blood and require coronary angiography (procedure using X-ray imaging to see the heart’s blood vessels) or a coronary revascularization (widening of coronary arteries). There are different methods to determine the severity of the of the obstruction. The two methods that will be compared in this study are:

  Vessel fractional flow reserve (vFFR) guided revascularization
  vFFR utilizes a commercially available computer program to calculate the portion of flow that goes through an obstruction based on images acquired during routine diagnostic angiography.

  Fractional flow reserve (FFR) guided revascularization
  FFR utilizes a commercially available computer program to calculate the portion of blood flow that goes through an obstruction based on pressures obtained with dedicated pressure wires that are inserted into the coronary arteries

  The adoption of FFR into daily practice has not been universal. FFR assessment requires the use of a dedicated pressure wires along with the administration of a hyperemic agent associated with temporary patient discomfort. Additionally, there is the perceived issue of additional time and cost needed to perform FFR.
  Technological developments allow to estimate this fractional flow reserve (portion of blood flow that goes through an obstruction) without using additional pressure wires, and it is important to determine if the benefits of both options are comparable.

• REC name

  Yorkshire & The Humber - Sheffield Research Ethics Committee

• REC reference

  22/YH/0004

• Date of REC Opinion

  14 Feb 2022

• REC opinion

  Further Information Favourable Opinion