Factors that predict compression outcome in lymphoedema
Research type
Research Study
Full title
A prospective study to identify factors that predict the performance of the 3M Coban 2 compression system (Coban 2 system) and Standard Compression used within Decongestive Lymphatic Therapy in Patients with Lymphoedema
IRAS ID
128257
Contact name
Christine Moffatt
Contact email
Sponsor organisation
Centre for Research & Implementation of Clinical Practice
Research summary
Lymphoedema is a chronic swelling caused by regional accumulation of lymphatic fluid due to an insufficient lymphatic system. The increased size and restricted mobility of the affected limb influences quality of life. In the intensive phase treatment is focused on volume reduction and breakdown of fibrosclerotic tissue via decongestive lymphatic therapy, a combination of bandaging, manual lymphatic drainage, exercises and skin care. Systematic reviews have confirmed the benefit of compression (Badger et al 2004). Recent research has begun to unravel the correct characteristics of a compression bandage for lymphoedema. Evidence would suggest that the use of bandages to reduce limb volume is highly variable in different patients. The aim of the present study is to gain further clinical experience on the effectiveness of the Coban 2 system in the treatment of patients with lymphoedematous legs and arms and to determine the factors that predict limb volume reduction over a period of up to 28 days intensive therapy. In addition a cohort of patients will use Best Practice (without the Coban 2 system) to determine similar factors. This may allow for greater targeting of appropriate management options in patients and allow for improved predictability of success in different patient groups. A comparison will be made between the two groups to determine the outcome of treatment for the two cohorts.
REC name
East of England - Cambridge Central Research Ethics Committee
REC reference
13/EE/0154
Date of REC Opinion
8 Jul 2013
REC opinion
Further Information Favourable Opinion