Factors predicting serum HLA antibody dynamics in kidney transplant
Research type
Research Study
Full title
Factors predicting serum HLA antibody persistence or decline in kidney transplant patients on the waiting list
IRAS ID
312873
Contact name
Ying Li
Contact email
Sponsor organisation
NHS Blood and Transplant
Duration of Study in the UK
1 years, 2 months, 30 days
Research summary
Human Leukocyte antigen (HLA) specific antibodies are measured prior to kidney transplantation. For a patient having these antibodies against the particular kidney donor, the cross-match will likely be positive (reactive) meaning that transplantation with that donor would be at high risk for rejection: these antibodies prevent transplantation. HLA antibodies can be stimulated by blood transfusion, pregnancy, and transplants. Some patients lose their antibodies fairly quickly (eg within months), whilst others sustain them for years, sometimes decades, and due to a lack of study this is currently unpredictable. The primary objective of this project is to predict what happens to kidney transplant waiting list patients’ HLA antibodies with time, which would help with patient management. The experimental approach will be to classify waiting list patient’s antibody dynamics and correlated this with clinical, demographic and other patient characteristics using machine learning and data modelling algorithms.
REC name
East Midlands - Derby Research Ethics Committee
REC reference
23/EM/0228
Date of REC Opinion
7 Nov 2023
REC opinion
Further Information Favourable Opinion