FAAR in children
Research type
Research Study
Full title
Identification of Future Asthma Attack Risk in Children with Clinical Tests
IRAS ID
337100
Contact name
Sejal Saglani
Contact email
Sponsor organisation
Imperial College London
Duration of Study in the UK
3 years, 6 months, 3 days
Research summary
This study aims to improve the lives of children with pre-school wheeze or asthma by developing a predictive score to identify those at risk of a future wheeze or asthma attack.
Biomarkers are indicators that can be measured easily to assess physiological processes. This study will include biomarkers of inflammation; blood cells called eosinophils and a breath test called exhaled nitric oxide (FeNO). In addition, breathing tests to assess how the lungs are working (lung function) will be measured. The aim is to identify the predictive value of blood eosinophils alone, or combined with FeNO, and/or lung function tests to identify children at risk of a future asthma attack in the next 3-4 months.
There are three main aims.
Aim 1 to see if blood eosinophil count can predict wheeze or asthma attacks in the following 3-4 months.
Aim 2 to see if lung function and/or FeNO and/or symptom control, with/without eosinophil count predicts asthma attacks in the following 3-4 months.
Aim 3 to prove the feasibility and acceptability of blood finger prick test, breath tests and lung function tests in a pragmatic clinic setting.Recruitment will occur in paediatric respiratory clinics, targeting children aged 1-16 years with a confirmed asthma diagnosis, or recurrent episodes of wheezing. All tests will be conducted over a year, at the time of the patient's clinic appointments.
REC name
Yorkshire & The Humber - Bradford Leeds Research Ethics Committee
REC reference
24/YH/0177
Date of REC Opinion
11 Sep 2024
REC opinion
Further Information Favourable Opinion