ExTra CKD

• Research type

  Research Study

• Full title

  Exercise Training in Chronic Kidney Disease

• IRAS ID

  137056

• Contact name

  Alice Smith

• Contact email

  aa50@le.ac.uk

• Sponsor organisation

  Research and Innovation

• Research summary

  Patients with Chronic Kidney Disease (CKD) suffer with muscle wasting which is an important clinical problem as it is strongly associated with morbidity and mortality and can begin very early in the disease process. It inevitably leads to an impaired quality of life and an extremely sedentary lifestyle which is also detrimental to health since we know that regular physical activity has many beneficial effects on metabolic and cardiorespiratory health. Previous studies have shown that the appropriate exercise can help increase muscle mass in pre-dialysis CKD patients. This is important as muscle mass in these patients is also a limiting factor for exercise capacity and may therefore also potentially limit the amount of aerobic exercise they are able to undertake, which has proven cardiovascular benefits in this high risk population.
  We know that separately aerobic exercise can help modify possible mediators of cardiovascular disease, and resistance exercise can help improve muscle mass in CKD patients, however, we don’t know if the exercise modalities can be combined to provide both improved cardiorespiratory fitness and protection of cardiac function together with increased muscle mass, or if the two interfere with each other and neither benefit is gained. This will indicate the best way to deliver programmes such as this to CKD patients.
  This research study will investigate the effect of a 12 week aerobic programme alone or in combination with resistance exercise. It will assess the effectiveness of a pragmatic exercise programme for this population and will provide data about:
  • the effect of aerobic and aerobic + resistance exercise on muscle mass and muscle strength, systemic inflammation and oxidative stress, and risk factors for cardiac disease
  • the effect of both exercise programmes on quality of life
  • the cellular, biochemical and molecular mechanisms involved in the above effects

• REC name

  East Midlands - Leicester South Research Ethics Committee

• REC reference

  13/EM/0344

• Date of REC Opinion

  22 Oct 2013

• REC opinion

  Further Information Favourable Opinion