Expression of P504s and P53 in Serrated Polyps of the Colon
Research type
Research Study
Full title
Expression of P504s and P53 in Serrated Polyps of the Colon: A Progression to Colorectal Adenocarcinoma?
IRAS ID
203691
Contact name
Dawn Chessor
Contact email
Sponsor organisation
NHS Highland
Duration of Study in the UK
0 years, 7 months, 3 days
Research summary
Until recently serrated polyps were thought to only consist of benign, innocuous hyperplastic polyps but recent advances in molecular pathogenesis has unveiled that morphologically serrated polyps are heterozygous lesions. Bowel screening programmes have also highlighted the histopathological examination of serrated polyps to be particularly problematic due to variations in diagnostic criteria. This is important as sessile serrated polyps, while bearing a histological resemblance to hyperplastic polyps, are associated with increased risk of developing colorectal adenocarcinoma. Therefore the need to find a marker which would aid the morphological distinction is desirable. This study will investigate the expression of P504s and P53 in serrated polyps, and whether these markers are useful in distinguishing sessile serrated polyps and hyperplastic polyps. The study will also consider the expression of the markers in colorectal cancer, and whether the levels change as colorectal adenocarcinoma develops. A total of 200 specimens will be included, each of which will have an H&E section and the necessary immunological staining.
REC name
East Midlands - Derby Research Ethics Committee
REC reference
16/EM/0390
Date of REC Opinion
1 Sep 2016
REC opinion
Favourable Opinion