Expression of P504s and P53 in Serrated Polyps of the Colon

  • Research type

    Research Study

  • Full title

    Expression of P504s and P53 in Serrated Polyps of the Colon: A Progression to Colorectal Adenocarcinoma?

  • IRAS ID

    203691

  • Contact name

    Dawn Chessor

  • Contact email

    dawn.chessor2@nhs.net

  • Sponsor organisation

    NHS Highland

  • Duration of Study in the UK

    0 years, 7 months, 3 days

  • Research summary

    Until recently serrated polyps were thought to only consist of benign, innocuous hyperplastic polyps but recent advances in molecular pathogenesis has unveiled that morphologically serrated polyps are heterozygous lesions. Bowel screening programmes have also highlighted the histopathological examination of serrated polyps to be particularly problematic due to variations in diagnostic criteria. This is important as sessile serrated polyps, while bearing a histological resemblance to hyperplastic polyps, are associated with increased risk of developing colorectal adenocarcinoma. Therefore the need to find a marker which would aid the morphological distinction is desirable. This study will investigate the expression of P504s and P53 in serrated polyps, and whether these markers are useful in distinguishing sessile serrated polyps and hyperplastic polyps. The study will also consider the expression of the markers in colorectal cancer, and whether the levels change as colorectal adenocarcinoma develops. A total of 200 specimens will be included, each of which will have an H&E section and the necessary immunological staining.

  • REC name

    East Midlands - Derby Research Ethics Committee

  • REC reference

    16/EM/0390

  • Date of REC Opinion

    1 Sep 2016

  • REC opinion

    Favourable Opinion