Exploring Genetic Predisposition to Foetal Anticonvulsant Syndromes
Research type
Research Study
Full title
Exploring Genetic Predisposition to Foetal Anticonvulsant Syndromes
IRAS ID
210387
Contact name
Jill Clayton-Smith
Contact email
Sponsor organisation
The University fo Manchester
Duration of Study in the UK
0 years, 7 months, 29 days
Research summary
Children exposed to antiepileptic drugs (AEDs) during pregnancy have a higher risk of medical problems at birth and with development. It is important to recognise that not all children exposed to AEDs during pregnancy have these problems and the reason why some children have and others do not have these difficulties is unclear.
Differences in the genetic code of children exposed to AEDs during pregnancy may put some children at risk of these problems. This study will look at the genetic makeup of children with foetal anticonvulsant syndrome (FACS) and explore any link with medical or developmental problems.
Patients with FACS will be identified through the local hospital records and database and their genetic testing will be reviewed to see any changes in the genetic code of affected children. Further cases will be identified through the Deciphering Developmental Disorders (DDD) study where more in depth genetic testing would have taken place. These results will be analysed to see any recurrent changes in genetic code which may put children at a higher risk.REC name
North West - Greater Manchester West Research Ethics Committee
REC reference
16/NW/0788
Date of REC Opinion
11 Nov 2016
REC opinion
Favourable Opinion