Experimental Human Pneumococcal Carriage: Asthma and immune function
Research type
Research Study
Full title
Experimental Human Pneumococcal Carriage Model (Programme Grant) The effect of asthma on immune response to pneumococcus
IRAS ID
199884
Contact name
Jamie Rylance
Contact email
Sponsor organisation
Liverpool School of Tropical Medicine
Duration of Study in the UK
3 years, 5 months, 1 days
Research summary
Background: Pneumococcus is a bacteria that can cause severe infection such as pneumonia, sepsis and meningitis in the very young, the very old and those with chronic conditions are particularly at increased risk.Vaccines protect against a few of the many sub-types of the pneumococcus bacteria. In addition, this bacteria is commonly present in the nose of healthy adults without any sign of illness (carriage), which may help develop natural immunity to the infection.
We have established an Experimental Pneumococcal Carriage Model (EHPC) that allows healthy volunteers to carry these bacteria in their nose safely. Over 500 healthy volunteers have taken part.Why?This study seeks an understanding of why people with asthma are at an increased risk of pneumonia due to this bacteria. We will use the EHPC model to study the immune response to pneumococcus in people with asthma.
Who? We will recruit adults aged 18-50 years,with mild well controlled asthma,on treatment with low dose inhaled corticosteroids.
Where? The study will be conducted at the clinical research facility in Royal Liverpool University Hospital. People with asthma will be recruited from advertising in local media,public places, pharmacies, primary care, hospital and university websites.
How? Part one will take 4-5 weeks. A few drops of the live bacteria are put into the nose then we collect secretions from the nose and take blood samples. Those who carry the bacteria will be invited to repeat this after 6-12 months to see if they have developed natural immunity. We ask participants to report any early signs of infection, we provide a thermometer and antibiotics to identify and treat infection early. The research team are available 7 days a week and will provide access to healthcare.
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
16/NW/0124
Date of REC Opinion
18 Mar 2016
REC opinion
Further Information Favourable Opinion