Exosomes as biomarkers of heart failure: V2
Research type
Research Study
Full title
Exosomal microRNAs as diagnostic biomarkers of heart failure
IRAS ID
232350
Contact name
Fiona Lewis
Contact email
Sponsor organisation
Queen Mary University of London
Duration of Study in the UK
0 years, 11 months, 28 days
Research summary
Heart failure (HF) is a leading cause of death in the UK and worldwide. At present there is no single diagnostic test for HF therefore new biomarkers are required to enable early diagnosis and provide efficient methods of monitoring/treating HF. In recent years, miRNAs have emerged as a potentially valuable diagnostic tool for damaged hearts. However due to considerable variability in patient cohorts and methods of detection, a lack of reliable evidence for the use of miRNAs as biomarkers for HF persist. Exosomes are nanosized particles capable of transferring molecules, including miRNA, to neighbouring cells. Due to their unique biology, exosome miRNA expression level changes appear to be more specific to disease states than total circulating miRNA. In this study we will determine how exosome-derived miRNAs can provide a reliable biomarker of HF. Exosomes will be isolated from HF and non-HF patient's serum and miRNA screening performed to identify disease-specific miRNA signatures that can be utilised as novel diagnostic/prognostic biomarkers thus having major impact on the future treatment of heart disease and failure.
REC name
North West - Greater Manchester West Research Ethics Committee
REC reference
18/NW/0084
Date of REC Opinion
15 Feb 2018
REC opinion
Further Information Favourable Opinion