EXERCISE CAPACITY IN PRIMARY SJÖGREN’S SYNDROME
Research type
Research Study
Full title
EXERCISE (AEROBIC) CAPACITY IN PRIMARY SJÖGREN’S SYNDROM: a pilot study
IRAS ID
168303
Contact name
Samira T. Miyamoto
Contact email
Sponsor organisation
Newcastle upon Tyne Hospitals NHS Foundation Trust
Duration of Study in the UK
0 years, 3 months, 1 days
Research summary
People with primary Sjögren`s Syndrome (pSS) typically present with dryness, pain and fatigue. Women are 15-20 times more likely to be affected. We know that dryness is caused by inflammation and damage of the moisture-producing glands such as the salivary and tear glands. However, the cause of pain and in particularly fatigue is unclear. The aim of this pilot study is to explore whether cardiorespiratory fitness is reduced in people with pSS and whether it is linked with fatigue. The secondary aims are to explore whether cardiorespiratory fitness is associated with other clinical features, quality of life, level of physical activity, depression, quality of life, and circulatory cytokines. We hypothesise that cardiorespiratory fitness to be lower in pSS and is associated with fatigue, which in turn may increase the risk of secondary complications such as cardiovascular diseases and diabetes.
PSS subjects will be identified and recruited through the UK pSS registry and from the local cohort of pSS patients attending the Sjogren’s syndrome clinic at the Freeman Hospital. Healthy control participants will be
recruited from a local cohort of 3,000+ volunteers (Voice North) who have agreed to be contacted about taking part in research.We will assess cardiorespiratory fitness using cardiopulmonary exercise testing (Treadmill test). Physical activity, depression and quality of life will be assessed using standardised questionnaires. PSS disease activity and serum circulatory cytokine levels will also be assessed.
32 women with pSS and 32 healthy women will be studied. The study (a single visit of approximate 1.5 hours) will be conducted in the MRC Muscle Performance and Exercise Training Laboratory (MoveLab), located in the Clinical Research Facility at the Royal Victoria Infirmary. Only anonymised data will be analysed and published. The study is funded by CAPES Foundation (Brazil) which fund the visiting student.
REC name
North East - Newcastle & North Tyneside 2 Research Ethics Committee
REC reference
15/NE/0333
Date of REC Opinion
10 Dec 2015
REC opinion
Further Information Favourable Opinion