EVOCC
Research type
Research Study
Full title
A randomised controlled trial assessing the clinical and cost-effectiveness of Endovascular vs. Open revascularisation in severe oCClusive aorto-iliac disease. The EVOCC Trial.
IRAS ID
323392
Contact name
Athanasios Saratzis
Contact email
Sponsor organisation
University of Leicester
Duration of Study in the UK
5 years, 8 months, 30 days
Research summary
Lower limb Peripheral Arterial Disease (PAD) is a form of severe occlusive aorto-iliac disease which affects one in five people over 55 years of age in the UK and is the main cause of leg amputations in the NHS. This is caused by blockages or narrowings in the arteries carrying blood to the leg(s). Some sufferers may develop leg pain when walking whereas others might have leg pain at rest or death of the tissue in the leg(s). This can be leg and life threatening and must be treated with surgery to save the leg or life. The surgery can use one of two common ways of getting more blood to the leg(s):
• Open surgery: this involves an operation to bypass the blocked/narrowed arteries
• Keyhole surgery: this involves inflating a balloon inside the blocked/narrowed arteries forcing them to open (angioplasty). Sometimes it is necessary to put a small metal tube into the artery to hold it open (stenting). This type of procedure is called endovascular treatment
Both open and keyhole surgery are currently offered to patients in the NHS.
This trial aims to understand which type of surgery is better for saving the legs and lives of patients with PAD, which type is less likely to lead to more surgery in the future and which is better cost-wise for the NHS.REC name
South West - Cornwall & Plymouth Research Ethics Committee
REC reference
23/SW/0065
Date of REC Opinion
22 May 2023
REC opinion
Favourable Opinion