Evaluation of the Effect of the OBJ Technology on Fluoride Uptake V3.0
Research type
Research Study
Full title
A Feasibility Study to Evaluate the Effect of the OBJ Technology on Fluoride Uptake
IRAS ID
149127
Contact name
Alice Bordas
Contact email
Sponsor organisation
GlaxoSmithKline Consumer Healthcare
Research summary
Fluoride is one of the main ingredients used in oral care products for protection from caries. The degree to which the fluoride is stored into the oral soft tissues and its slow release over time in saliva is a determining factor in caries protection.
This is a single centre, double blind, randomised, two treatment crossover study in healthy subjects.
The purpose of this study is to assess the potential of a magnetic strip (OBJ™ technology) to increase fluoride uptake from a fluoride mouthrinse to the mouth tissues and subsequent release in saliva as compared to a placebo strip (a strip with no magnetic properties) over a period of 120 minutes.
Further, the amount of fluoride remaining in the mouth after 120 minutes will be assessed by asking the subjects to rinse with grapefruit juice, which will extract the fluoride left in the mouth.
The salivary samples and grapefruit juice expectorate will be analysed on the same day for fluoride using Gas Chromatography.REC name
London - City & East Research Ethics Committee
REC reference
14/LO/1037
Date of REC Opinion
4 Jun 2014
REC opinion
Favourable Opinion