Evaluation of pain associated with chronic venous insufficiency
Research type
Research Study
Full title
The evaluation of pain severity in the lower limb caused by Chronic venous insufficiency.
IRAS ID
280008
Contact name
Mohammad Aslam
Contact email
Sponsor organisation
Imperial College London and Imperial College Healthcare NHS Trust
Clinicaltrials.gov Identifier
Duration of Study in the UK
4 years, 7 months, 21 days
Research summary
Chronic venous insufficiency occurs when your leg veins don’t allow blood to flow back up to your heart. Normally, the valves in your veins make sure that blood flows toward your heart. But when these valves don’t work well, blood can also flow backwards. This can cause blood to collect (pool) in the legs.Chronic venous disease is a highly prevalent condition in the general population, and it has a significant impact on quality of life. While it is usually manifested by obvious signs, such as varicose veins and venous ulcers, other symptoms of the disease are less specific. Among the other symptoms, which include heaviness, swelling, muscle cramps and restless legs, pain is the symptom that most frequently compels CVeD patients to seek medical aid. However, there is a substantial discrepancy between pain severity and clinically detectable signs of CVeD, questioned by several opposing studies. Further evaluation is needed to clarify this subject, and to analyse whether pain development predicts objective tool to evaluate pain by dosflexin exercise pre surgery and post and measure the severity of pain by heat stimualation . General management of CVeD starts with advising lifestyle .
Patients with chronic venous insufficiency will be assessed before and after treatment using contact heat evoked potential (CHEPS) and visual dialog scale ( VAS ) to estimate the pain intensity the severity of the pain before the patient do exercise before three moths of leaser endovenous ablation procedure .
2-photo-plethysomography Non invasive technique , pp sensor emit infrared light detects changes in reflection from epiderma layer .
Vessels full of blood reflect 10 times less than without blood .
On dorsiflexion - pressure drops, increasing reflection in the measuring window Venous assessment the venous refill time, is shorter and typically less than 20 s .REC name
North of Scotland Research Ethics Committee 1
REC reference
21/NS/0148
Date of REC Opinion
26 Nov 2021
REC opinion
Unfavourable Opinion