Evaluation of lifestyle modification on cardiovascular risk
Research type
Research Study
Full title
Evaluation of lifestyle modification on cardiovascular risk in overweight and obese postmenopausal women: a ghrelin-mediated response
IRAS ID
314505
Contact name
Rachel Churm
Contact email
Sponsor organisation
Swansea University
Duration of Study in the UK
2 years, 11 months, 30 days
Research summary
Postmenopausal women are at increased risk of metabolic stress. This can be due to two main factors; an increase in fat stored centrally within the abdomen and the loss of protective agents for your heart’s health. These factors in addition to low levels of physical activity can have a negative effect on your health. The way our body stores fat can be linked to poor blood sugar levels and can result in the development of diseases such as diabetes & heart disease. Lifestyle modifications like exercise and diet have shown to improve many aspects of health, such as weight management, blood sugar levels, and heart health. However, it is not fully understood, the pathway in which changes in your lifestyles, such as increased levels in exercise training with or without diet control, acts to have a beneficial effects within postmenopausal women. We want to explore how this relationship can impact proteins within the stomach that can control fat storage and blood sugar usage, as well as protection against heart and metabolic diseases.
This study will look at how exercise with or without the Mediterranean diet changes the way our body can promote heart and metabolic health benefits through the pathway of stomach proteins, without the use of drugs. This project has a goal of improving our knowledge of how we can use lifestyle modifications as an alternative treatment against conditions such as type 2 diabetes and obesity. The purpose is to improve our knowledge of exercise with or without the Mediterranean diet in relation to related stomach proteins and pathway-related chemicals in our body, and how these might be important in ill-health related to diabetes and the metabolic state.REC name
London - Hampstead Research Ethics Committee
REC reference
22/LO/0301
Date of REC Opinion
19 Apr 2022
REC opinion
Favourable Opinion