Evaluation of host and microbial factors in discard respiratory sample [COVID-19]
Research type
Research Study
Full title
Evaluation of host and microbial factors in discard respiratory sample
IRAS ID
282319
Contact name
Vilas Navapurkar
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust
Duration of Study in the UK
1 years, 8 months, 31 days
Research summary
COVID19 leading to severe acute respiratory syndrome is a major challenge for the world, and it is leading to significant pressure on hospital services generally and critical care services specifically. Amongst patients who require mechanical ventilation there is a need to obtain deep lung samples for both the detection of the COVID19 virus (SARS-cov2) and for the diagnosis of secondary infection. In viral pneumonitis (lung inflammation) from other viruses we know that the normal ’microbial flora’ (normal bacteria that live in the lung in health) is disrupted, and that this may lead to overgrowth of harmful bacteria and secondary infection. Patients ventilated for COVID19 appear to be at high risk of secondary infection. This study will use surplus sample left over from clinical testing to assess the effects of covid19 infection on the ’microbial flora’ of the lung, and to assess the response of the patient’s own immune system in the lungs and how these change as patients develop secondary infection. There is very limited existing information available on lung-specific changes in microbes and the bodies response, despite this being a major focus of the disease.
REC name
Yorkshire & The Humber - Leeds West Research Ethics Committee
REC reference
20/YH/0152
Date of REC Opinion
23 Apr 2020
REC opinion
Favourable Opinion