Evaluation of EF1 to guide cardiac resynchronisation therapy
Research type
Research Study
Full title
Evaluation of first-phase ejection fraction to guide cardiac resynchronization therapy
IRAS ID
321047
Contact name
Haotian Gu
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
5 years, 0 months, 0 days
Research summary
Cardiac Resynchronization Therapy (CRT) reduces morbidity and mortality in patients with severe left ventricular systolic impairment and electrical dyssynchrony. However, even in carefully selected cases, up to 30% of patients fail to respond and selection of patients is recognised to be a major challenge. First-phase ejection fraction (EF1) is a simple but novel measure of early systolic function that may identify the potential of the myocardium to respond to CRT. In a retrospective study, we found EF1 to have striking predictive value for response to CRT. Furthermore, improvement of EF1 at 6-months post CRT was a better predictor of clinical outcome than the reverse remodelling of the ventricle currently used to predict outcomes. The purpose of the present application is 1) to verify in a multi-centre prospective study that EF1 is sufficiently robustly predictive of CRT response so as to be useful in guiding the selection of patients for CRT; 2) investigate whether EF1 could be used as a target against which CRT parameters can be optimised; 3) to examine the relationship between global and regional early systolic function to understand how response to CRT relates to regional early systolic function and the inherent contractile function of the myocardium.
REC name
North of Scotland Research Ethics Committee 2
REC reference
23/NS/0069
Date of REC Opinion
20 Jun 2023
REC opinion
Favourable Opinion