Evaluating treatable traits in chronic obstructive airways diseases
Research type
Research Study
Full title
Evaluating treatable traits across the spectrum of chronic obstructive airways disease
IRAS ID
323694
Contact name
Oliver Price
Contact email
Sponsor organisation
University of Leeds
Duration of Study in the UK
2 years, 0 months, 30 days
Research summary
Respiratory disease affects one in five people and is a leading cause of morbidity and mortality in the UK. Chronic obstructive airways diseases (CAD) encompass conditions characterised by expiratory airflow limitation, exertional dyspnoea, activity limitation and impaired quality of life. The most common conditions include chronic obstructive pulmonary disease (COPD) (emphysema +/- chronic bronchitis), asthma, bronchiectasis and cystic fibrosis. In recent years, there has been concerted effort in the scientific and respiratory medicine community to improve the diagnosis and management of CAD using personalised or precision medicine (i.e., tailoring therapies and interventions according to specific “treatable traits”) and identifying phenotypes or endotypes using validated biomarkers. To date, however, research in this setting has primarily focussed on people with COPD and asthma, with limited studies in other disease subtypes. The primary aim of this project is therefore to identify key factors associated with activity limitation and impaired quality of life across the spectrum of chronic obstructive airways disease. A secondary objective is to determine how disease specific traits associate with patient-reported outcomes; (i.e., symptoms, physical activity and functional status etc.) and develop personal lifestyle interventions to improve clinical outcomes and quality of life. To achieve these objectives, participants will undergo pulmonary function tests, maximal / submaximal exercise testing, peripheral muscle strength assessments, analysis of body composition, complete lifestyle questionnaires and objective real world physical activity monitoring over a 24-month period at Leeds Teaching Hospital Trusts, or the University of Leeds. Adults aged 18-65 years will be eligible for the study if they have an existing CAD with moderate or moderate-severe airway obstruction.
REC name
London - City & East Research Ethics Committee
REC reference
23/LO/0465
Date of REC Opinion
6 Jul 2023
REC opinion
Further Information Favourable Opinion