Evaluating thromboelastography (TEG) and ETP in sickle adults
Research type
Research Study
Full title
Assessing the utility of thromboelastography (TEG) and Endogenous Thrombin Potential (ETP) in adults with sickle cell disease
IRAS ID
198152
Contact name
Beverley Hunt
Contact email
Sponsor organisation
Guy's & St Thomas' Foundation NHS Trust
Duration of Study in the UK
0 years, 2 months, 14 days
Research summary
Our objective is to use thromboelastography(TEG) and Endogenous Thrombin Potential (ETP) which are both laboratory assays which measures how quickly blood clots, in well (steady state) adult patients with sickle cell disease (SCD) and compare the findings in this group to acutely admitted patients with sickle cell crises, also to SCD patients on a regular transfusion program and as well as well SCD patients being managed on a medication called Hydroxycarbamide. The results in the SCD patients will also be compared to healthy race matched control subjects. To better understand the higher rates of blood clots reported in SCD patients and also to assess the usefulness of TEG assays in this patient group.
Race matching of the control subjects is being carried out because of the well reported racial differences in coagulation parameters that exist in healthy individuals.
We are aiming to assess the reported prothrombotic state (this is a higher rate of clot formation) using TEG and ETP in different clinical settings in adult patients with SCD and we will compare the results of this method of testing to the conventional haemostatic (clotting assays) in blood samples collected at the same time.REC name
East of England - Cambridge East Research Ethics Committee
REC reference
16/EE/0114
Date of REC Opinion
29 Mar 2016
REC opinion
Further Information Favourable Opinion