Evaluating the role of coronary disease in Type 2 MI (EVEREST-MI)
Research type
Research Study
Full title
Evaluating the role of coronary artery disease to resolve the diagnosis of Type 2 Myocardial Infarction
IRAS ID
228178
Contact name
Andrew Chapman
Contact email
Sponsor organisation
University of Edinburgh
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
A heart attack is usually caused when a fatty plaque in a heart arteries ruptures, and a blood clot prevents the supply of oxygen to the heart muscle, causing permanent damage. This is called a type 1 myocardial infarction. We diagnose a heart attack using a heart tracing or electrocardiogram, and a blood test which measures troponin, a heart muscle protein released when heart muscle dies.
We now recognise heart muscle damage may happen when the artery is not completely blocked. We see this in patients with insufficient oxygen in the blood due to another illness such as a chest infection, or when the heart is beating too fast to receive enough oxygen. This is called a type 2 myocardial infarction, or myocardial injury. These patients have a very poor outcome, with a high risk of future heart attacks and as few as 1 in 3 surviving for five years.
We think it is likely these patients have underlying coronary artery disease, which is responsible for the higher risk of future heart attacks or death. We propose a study of 100 patients in hospital with suspected type 2 myocardial infarction to undertake invasive or non-invasive tests to look for coronary artery disease. We will also undertake a detailed MRI scan to study the pattern of heart muscle damage, which may influence treatment. We believe the majority of patients will have coronary artery disease.
REC name
South East Scotland REC 01
REC reference
17/SS/0078
Date of REC Opinion
31 Jul 2017
REC opinion
Further Information Favourable Opinion