Evaluating the role of coronary disease in Type 2 MI (EVEREST-MI)

  • Research type

    Research Study

  • Full title

    Evaluating the role of coronary artery disease to resolve the diagnosis of Type 2 Myocardial Infarction

  • IRAS ID

    228178

  • Contact name

    Andrew Chapman

  • Contact email

    a.r.chapman@ed.ac.uk

  • Sponsor organisation

    University of Edinburgh

  • Duration of Study in the UK

    3 years, 0 months, 0 days

  • Research summary

    A heart attack is usually caused when a fatty plaque in a heart arteries ruptures, and a blood clot prevents the supply of oxygen to the heart muscle, causing permanent damage. This is called a type 1 myocardial infarction. We diagnose a heart attack using a heart tracing or electrocardiogram, and a blood test which measures troponin, a heart muscle protein released when heart muscle dies.

    We now recognise heart muscle damage may happen when the artery is not completely blocked. We see this in patients with insufficient oxygen in the blood due to another illness such as a chest infection, or when the heart is beating too fast to receive enough oxygen. This is called a type 2 myocardial infarction, or myocardial injury. These patients have a very poor outcome, with a high risk of future heart attacks and as few as 1 in 3 surviving for five years.

    We think it is likely these patients have underlying coronary artery disease, which is responsible for the higher risk of future heart attacks or death. We propose a study of 100 patients in hospital with suspected type 2 myocardial infarction to undertake invasive or non-invasive tests to look for coronary artery disease. We will also undertake a detailed MRI scan to study the pattern of heart muscle damage, which may influence treatment. We believe the majority of patients will have coronary artery disease.

  • REC name

    South East Scotland REC 01

  • REC reference

    17/SS/0078

  • Date of REC Opinion

    31 Jul 2017

  • REC opinion

    Further Information Favourable Opinion