Ethnic differences in aspirin response (1/9/2010)

• Research type

  Research Study

• Full title

  ETHNIC DIFFERENCES IN ASPIRIN RESISTANCE AND CARDIOVASCULAR DISEASE: ROLE OF DIABETES

• IRAS ID

  56080

• Contact name

  Gregory Lip

• Sponsor organisation

  Sandwell and West Birmingham NHS Trust

• Eudract number

  2009-017176.25

• ISRCTN Number

  n/a

• Research summary

  South Asians and diabetics are at an increased risk of heart attack and stroke that are caused by a blood clot in a crucial artery. One possible reason for this increased risk is that the tiny blood cells called platelets that form the clot are more likely to do so. One way of finding out if someone's platelets are more active in this respect is by looking at their response to the most common anti-platelet drug we have - aspirin. It might be that South Asians and diabetics are at a high risk because their platelets are resistant to the standard dose of aspirin of 75 mg every day. If, as we suspect, this is indeed the case, we will try to overcome (i.e. 'cure') this aspirin resistance by giving them more aspirin - a dose of 300 mg each day. Should this approach be successful we will have identified a very simple way to reduce the risk of heart attack and stroke.

• REC name

  West Midlands - Edgbaston Research Ethics Committee

• REC reference

  10/H1208/40

• Date of REC Opinion

  2 Sep 2010

• REC opinion

  Further Information Favourable Opinion