ESGO quality indicators for advanced ovarian cancer surgery
Research type
Research Study
Full title
Assessment of the prognostic impact of the published European Society of Gynecologic Oncology quality indicators for advanced ovarian cancer surgery.
IRAS ID
328779
Contact name
Alexandros Laios
Contact email
Sponsor organisation
Leeds Teaching Hospitals NHS Trust
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
0 years, 6 months, 3 days
Research summary
Multiple studies have confirmed that centralization improves outcomes in women with advanced stage ovarian carcinoma (OC) due to complex treatment algorithms including extensive cytoreductive surgery. Therefore, the European Society of Gynaecological Oncology (ESGO) has established and published 10 quality indicators for centers performing advanced stage OC surgery. Based on these quality indicators, ESGO runs institutional accreditation processes for advanced stage OC surgery in two categories, i.e. regular accreditation and centers of excellence. No large international multicenter study has yet validated the ESGO quality indicators. The present study will assess the prognostic impact of the established ESGO quality indicators for advanced stage OC surgery in a large international, multicenter study comprising all ESGO accredited centers. These will provide clinical data on the 10 ESGO quality indicators in ovarian cancer surgery and follow-up data on progression-free (PFS) and overall survival (OS) for the past three years, i.e. 2020, 2021, and 2022. Data will only be collected for patients who have initially presented at the respective center in Q1 and Q2 (6-month period) in these past three years. The following cohorts will be included 1) All consecutively incoming patients at the center with newly diagnosed advanced stage OC (irrespective of whether they underwent surgery or not during their primary therapy) 2) All recurrent OC patients who
underwent secondary of tertiary cytoreductive surgery at the center (importantly, surgical cases only). The primary objective is to evaluate the prognostic impact of the 10 ESGO quality indicators in advanced stage OC surgery on PFS. Secondary objectives will comprise associations between the ESGO quality indicators and OS, and prognostic implication of center’s accreditation status.REC name
North East - Newcastle & North Tyneside 1 Research Ethics Committee
REC reference
23/NE/0229
Date of REC Opinion
19 Dec 2023
REC opinion
Favourable Opinion