Epidemiology of diabetic retinopathy in type 1 diabetic patients (v1)
Research type
Research Study
Full title
Prevalence and Progression of Diabetic Retinopathy in Type 1 Diabetic Patients and the Relationship to Risk Factors including Duration of Diabetes
IRAS ID
177795
Contact name
Radhika Krishnan
Contact email
Sponsor organisation
University Hospital Southapton NHS Foundation Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
The Winchester Cohort includes 750 patients with type 1 diabetes who attended the specialist diabetes clinic service in Winchester, Eastleigh and Andover from 12 local postcodes served by the former Winchester and Eastleigh Healthcare Trust and registered on the Diamond Diabetes Database (from 1995 onwards). All patients in this group have type 1 diabetes and have accessible health care records including information on the duration of diabetes, other systemic factors and lifestyle factors (e.g. smoking).
We intend to collect further data for this cohort on the presence and severity of diabetic eye disease, as detected by the Southampton Diabetic Eye Screening Programme (SDESP). Data from the SDESP has been recorded on the Optomize computer system from 2008 onwards. We would collect this data from Optomize as well as the University Hospital Southampton NHS Foundation Trust eDocs records where necessary. No sensitive data will be accessed or stored during this process.
Having collecting this data retrospectively from 2008 until the present we can address the following important epidemiological questions:
- What is the prevalence of diabetic retinopathy in a cohort of type 1 diabetic patients as identified by the SDESP?
- How does prevalence relate to the duration of type 1 diabetes?
- How does the prevalence of diabetic retinopathy relate to other potential risk factors such as smoking, blood pressure and renal function?
- What is the risk of progression of diabetic retinopathy in this type 1 diabetic cohort over the period of the study?This study would provide up to date information on the epidemiology of diabetic eye disease in patients with type 1 diabetes. This body of new information should provide clear answers to the above research questions and be applicable to the general population, enabling clinicians to better inform their type 1 diabetic patients with diabetic retinopathy.
REC name
South Central - Hampshire A Research Ethics Committee
REC reference
15/SC/0374
Date of REC Opinion
3 Sep 2015
REC opinion
Further Information Favourable Opinion