Enteric adenovirus sequencing & evolutionary analysis (EASEA)
Research type
Research Study
Full title
Investigating the molecular epidemiology and evolution of enteric adenoviruses in England through whole-genome sequencing of IID and IID2 samples
IRAS ID
335914
Contact name
Charlotte Houldcroft
Contact email
Sponsor organisation
University of Cambridge
Duration of Study in the UK
1 years, 11 months, 31 days
Research summary
Adenoviruses are ancient and diverse family of human viruses which can cause gastro-intestinal infection. Children are particularly affected, with symptoms of infection including nausea, fever, diarrhoea and vomiting. In rare cases, enteric adenovirus infection has been associated with liver problems in children. This research project will study how the genetic material of enteric adenoviruses have evolved over the last two decades. This may identify changes in the virus associated with more severe disease, and will help with future efforts to design a vaccine for enteric adenovirus infection.
All of the samples to be used in the project were donated to the study of infectious intestinal disease in the community (IID) and IID2 projects with consent for future use, but ethical permission from REC must be obtained before any specific project can take place.
REC name
South Central - Berkshire Research Ethics Committee
REC reference
24/SC/0033
Date of REC Opinion
10 Jan 2024
REC opinion
Favourable Opinion