ENHANCE-D
Research type
Research Study
Full title
ENHANCE-D: Enhancing Dental Health Advice
IRAS ID
1004761
Contact name
Richard Holliday
Contact email
Sponsor organisation
The Newcastle upon Tyne Hospitals NHS Foundation Trust
Eudract number
2021-005440-30
ISRCTN Number
ISRCTN13158982
Research summary
Smoking is one of the main risk factors for oral (mouth) diseases, particularly periodontitis (gum disease) and cancer. Although there is evidence that giving up smoking leads to improvements in oral health, there is less evidence about how dental professionals can best support smokers to quit. This trial aims to address this, building on existing evidence by comparing the clinical- and cost-effectiveness and safety of three possible strategies for quitting smoking – nicotine replacement therapy (gum/patches - NRT); E-cigarettes (EC); and very brief advice from a dental professional (VBA). Success will be measured in terms of quit rates and improvement in oral health. The trial will be conducted in 56 NHS dental practices across 7 UK regional hubs in England and Scotland. 1460 adult regular tobacco smokers will be recruited, with 455 of those with periodontitis going into a sub-group for additional examination and analysis. All study participants will be randomly assigned to receive one of the three strategies described above. Those who are assigned to NRT or EC will be provided with a 12 week supply of NRT, or an EC starter kit. All participants will be followed up at 6 months and 12 months, with those in the periodontitis group having an additional clinical examination at 6 months. We will use a monitor that measures exhaled carbon monoxide to indicate whether the participants have stopped smoking, and for the periodontitis group we will take samples from their mouth and assess other indicators to measure their gum health. The trial is being funded by the National Institute for Health Research Health Technology Assessment programme, part of the Department of Health and Social Care.
REC name
North East - Tyne & Wear South Research Ethics Committee
REC reference
22/NE/0040
Date of REC Opinion
5 Apr 2022
REC opinion
Further Information Favourable Opinion