Endothelial function, inflammation and organ dysfunction in COVID-19 [COVID-19]
Research type
Research Study
Full title
Endothelial function, inflammation, and organ dysfunction in critically ill patients with COVID-19 infection
IRAS ID
282930
Contact name
Marlies Ostermann
Contact email
Sponsor organisation
Guy's & St Thomas' NHS Foundation Hospital
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
COVID-19 is a rapidly evolving pandemic with approximately 5% of all patients which require intensive care unit admission. In critically ill patients with COVID-19, approximately 15% had severe shock requiring medications to increase blood pressure. It appears that blood vessel tone is altered and microcirculation is not well regulated in patients with COVID-19. The underlying pathophysiology and contributing factors are unknown. The association with subsequent organ dysfunction and outcome is also unclear.\nTherefore, we aim to investigate serial changes of relevant biomarkers in this population to improve the understanding of this disease, to investigate the association with clinically important outcomes and to find out how best to treat patients. The data will serve to develop strategies for individualised management of this high-risk group.
REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
20/NW/0317
Date of REC Opinion
3 Aug 2020
REC opinion
Further Information Favourable Opinion