Endoscopic Submucosal Dissection Cohort Study Version 1.0
Research type
Research Study
Full title
Endoscopic Submucosal Dissection in the Treatment of Early Gastrointestinal Neoplasia: A Cohort Study to Assess Effectiveness and Safety
IRAS ID
203989
Contact name
Pradeep Bhandari
Contact email
Sponsor organisation
Portsmouth Hospitals NHS trust
Duration of Study in the UK
5 years, 0 months, 0 days
Research summary
Endoscopic submucosal dissection (ESD) is a technique used to treat early cancer within the gastrointestinal tract. This technique was first developed in Japan though is now being practised in the West. An endoscopic knife is used to gently peel away the cancer in its entirety. This has led to excellent outcomes. Since the growth is removed in one piece there is a higher chance of achieving a complete cure and preventing recurrence. A difficulty, however, with the technique is the higher risk of complications such as bleeding and perforation. A high level of endoscopic expertise mitigates this risk.
There have been several studies mainly from Japan and Europe on the outcomes of this technique in the removal of early cancer. These studies have shown that ESD is useful in removing superficial gastrointestinal cancers in their entirety and are better than conventional endoscopic resection techniques in minimising cancer recurrence. Given the length of time taken to learn ESD and the high level of expertise required, the procedure is only carried out in a few centres in the UK.
We wish to study the safety and efficacy of this procedure in the UK. This will help guide future practice and may allow for adaptation of this technique to suit the current healthcare setting.
Patients undergoing ESD for early cancerous growths in the gastrointestinal tract will be invited to take part in this study. Patients who have consented to take part will have information collected on the rate of cancer removal (in a single piece), cure rate and complication rates. They will also be followed up at standard intervals over 2 years to record information on cancer recurrence.REC name
East of Scotland Research Ethics Service REC 2
REC reference
16/ES/0074
Date of REC Opinion
1 Jun 2016
REC opinion
Favourable Opinion