Endorings™ assisted colonoscopy for polyp detection (version 1.0)
Research type
Research Study
Full title
Endorings™ assisted colonoscopy versus standard colonoscopy for polyp detection in symptomatic and asymptomatic patients: A randomised controlled trial.
IRAS ID
188034
Contact name
Pradeep Bhandari
Contact email
Duration of Study in the UK
1 years, 2 months, 0 days
Research summary
Bowel cancer is the second leading cause of cancer deaths in the UK, with over 16,000 people dying from it each year. Most cancers develop from benign polyps in the bowel, which are usually non-cancerous.
A colonoscopy is a telescopic camera test of the bowel used to detect bowel cancer or polyps. Polyps are common and have the potential to develop into cancer. Adenoma is a type of polyp that is more likely to develop into cancer. This transformation occurs over the course of years to decades. Hyperplastic polyps are the other main type. They rarely develop into cancer. It is not always possible to distinguish hyperplastic polyps from adenomas during colonoscopy. They are therefore frequently removed for microscopic examination for confirmation.
An aim of colonoscopy is to find and remove as many polyps as possible from the colon. Depending on the number and size of polyps detected and removed, there are guidelines to determine when the colonoscopy should be repeated to check for re-growth of polyps. Polyps can be small and difficult to detect. Studies have shown that even when performed by experts, up to 25% of polyps are missed during colonoscopy. They can commonly be hidden behind folds (a normal feature) in the bowel. Therefore, new ways to perform colonoscopy are required so that polyp miss rates can be reduced.
We aim to test one such method-the Endorings™. This device is attached to the end of
conventional colonoscopes to enhance mucosal views and tip control during colonoscopy. We will be inviting patients referred for investigation or surveillance to participate in the trial. If they accept, they will be randomly allocated to one of two groups;
I. Standard colonoscopy
II. Colonoscopy with endorings attached.
We will measure which groups have more polyps detected overall.REC name
South Central - Hampshire B Research Ethics Committee
REC reference
15/SC/0630
Date of REC Opinion
3 Nov 2015
REC opinion
Favourable Opinion