Endodontic-periodontal lesions - microbiome and treatment outcomes.
Research type
Research Study
Full title
Endodontic-periodontal lesions - comparison of treatment outcome using conventional and hydraulic calcium silicate sealer with or without LPRF and characterisation of host-microbiome interaction.
IRAS ID
309949
Contact name
Sadia Niazi
Contact email
Sponsor organisation
King's College London
Clinicaltrials.gov Identifier
Duration of Study in the UK
10 years, 0 months, 0 days
Research summary
In this study, we are assessing a specific oral disease, which involves combined infection of the tooth and the gums (Endo-perio diseases). Specifically, we are interested in looking at how to best treat these teeth and how these combined diseases impact on the body’s overall health.
Teeth with combined infections generally have a poor outlook and are challenging to treat. Moreover, there is a lack of evidence as to which specific treatment results in the best outcome.
In this study, the infected tooth will be cleaned from the inside (known as root canal treatment), followed by use of a material within the internal channels of the tooth. This is part of routine care, but there are some novel materials which has shown promising results.
An infected tooth which is also affected by gum disease will require deep cleaning of the external root surfaces. Due to the severe bone loss, these teeth may require gum surgery and where possible, we will use bone replacement materials to “regrow” gum and bone, as part the gold standard treatment for regenerative gum procedures.
To promote bone regrowth and healing, additional use of a blood -derived product from the patient, known as platelet rich fibrin (PRF) might be used during the gum surgery. This is completely natural as it is obtained from you by taking a blood sample. The use of this product is novel in dentistry, but so far, studies have shown good results.
Therefore, this study will assess the success of using these novel treatments on these combined diseases, as well as how these combined dental diseases impact on the body’s overall health.REC name
London - Bloomsbury Research Ethics Committee
REC reference
23/LO/0408
Date of REC Opinion
17 May 2023
REC opinion
Unfavourable Opinion