Endodontic-periodontal lesions - microbiome and treatment outcomes.
Research type
Research Study
Full title
Endodontic-periodontal lesions - comparison of treatment outcome using conventional and hydraulic calcium silicate sealer with or without LPRF and characterisation of host-microbiome interaction.
IRAS ID
309949
Contact name
Sadia Niazi
Contact email
Sponsor organisation
King's College London
Clinicaltrials.gov Identifier
Duration of Study in the UK
10 years, 0 months, 0 days
Research summary
In this study, we want to investigate a specific oral disease, which involves combined infection of the tooth and the gums (Endodontic-periodontal diseases). These combined infections have been challenging to treat, involving a multidisciplinary approach including tooth root canal treatment and gum disease therapy.
The tooth root canal treatment involves cleaning and disinfection of the tooth root canal system. This is followed by filling of the tooth root canal with root filling materials including conventional sealers and gutter percha. Lately, some biocompatible sealers (hydraulic calcium silicate sealers) which have been used for root canal treatments have shown good results.
The gum disease treatment consists of an initial phase of non-surgical therapy, followed by a reassessment to assess the response to treatment. Residual sites would be treated by surgical corrective therapy, and where possible regenerative periodontal treatment using a combination of bone substitute and biocompatible collagen membrane is carried out. Leukocyte – platelet rich fibrin (L- PRF) is derived from blood drawn from patients. This consists of a rich mix of platelets, growth factors and stem cells which can encourage wound healing process. Both hydraulic calcium silicate sealer and L-PRF have shown promising results in small scale studies but its efficacy in the treatment of endodontic-periodontal infections remains to be determined. Therefore, in this study we are investigating the efficacies of these approaches for the treatment of endodontic-periodontal infections, as well as the relationship between the oral microbiome and body’s immune response in these dental diseases.REC name
North of Scotland Research Ethics Committee 2
REC reference
23/NS/0023
Date of REC Opinion
16 Mar 2023
REC opinion
Unfavourable Opinion