Endocrine disrupting chemicals in adipose tissue of diabetics
Research type
Research Study
Full title
Association of endocrine disruption chemicals sequestered in peri-pancreatic and visceral adipose tissue in subjects with and without diabetes, and its correlation to microRNA profiles endocrine disruption chemicals in adipose tissue of type 1 and 2 diabetics.\n
IRAS ID
217657
Contact name
Titus Augustine
Contact email
Sponsor organisation
Central Manchester University Hospitals NHS Foundation Trust
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
There is increasing evidence that endocrine disrupting chemicals (EDCs) derived from environmental contamination are associated with diabetes either directly or indirectly through the association of increased obesity (environmental obesogens). EDCs are a diverse group of chemicals ingested through food contamination. Research has suggested that these EDCs may disrupt normal developmental controls over fat deposition and energy balance.Most of the evidence points to a relationship with type 2 diabetes (T2D) thought there are animal data to suggest that EDC may have a role in the development of type 1 diabetes.Environmental chemicals that can act as endocrine disruptors may affect the development and function of the immune system in ways that could promote the development of type 1 diabetes. Genetic research is establishing the importance of micro RNAS which are important for multiple gene regulation, and their importance in diabetes is increasingly recognized. Thus the presence of EDC in the tissue will be related to the microRNA profile in that tissue in patients with type 1 and 2 diabetes compared to weight and age matched control subjects. We will obtain discarded fat tissue from diabetic patients undergoing transplantation and also fat removed at the time of organ donation as controls.
REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
17/NW/0055
Date of REC Opinion
28 Mar 2017
REC opinion
Further Information Favourable Opinion