Eight week pilot study of HFAO in COPD
Research type
Research Study
Full title
An eight week pilot study to investigate the effect of high-frequency airway oscillation on breathlessness in patients with chronic obstructive pulmonary disease.
IRAS ID
201676
Contact name
Sally Singh
Contact email
Sponsor organisation
University Hospitals of Leicester NHS Trust
ISRCTN Number
ISRCTN81979106
Duration of Study in the UK
0 years, 8 months, 31 days
Research summary
This is a pilot study to investigate the appropriateness of High Frequency Airway Oscillations (HFAO) in Chronic Obstructive Pulmonary Disease (COPD). Participants will be required to attend on two occasions. Baseline measurements will include: maximum inspiratory pressure testing (MIP), maximum expiratory pressure testing (MEP), Hospital Anxiety and Depression Score (HADS), Leicester cough questionnaire (LCQ), Chronic Respiratory Questionnaire (CRQ), London Chest Activity of Daily Living Score (LCADLS), Borg breathlessness scale, Incremental Shuttle Walk Test and Endurance Shuttle Walk Test (ISWT, ESWT). Participants will use an oscillatory medical device for 3 sets of 5 minutes (or equivalent) at a setting of 25Hz and as required for sputum clearance at a setting of 15Hz. Participants will be followed up by telephone consultation weekly and asked to keep a daily diary of adherence. After eight weeks participants will repeat baseline measurements. Once the trial has been completed, participants will be invited to attend a dissemination discussion to discuss results and gather feedback on the study.
REC name
London - Central Research Ethics Committee
REC reference
16/LO/0924
Date of REC Opinion
24 May 2016
REC opinion
Further Information Favourable Opinion