EHPC: Establishing a Model Using SPN3

• Research type

  Research Study

• Full title

  Experimental Human Pneumococcal Challenge (EHPC) Model: Establishing SPN3 Challenge Model

• IRAS ID

  263376

• Contact name

  Andrea Collins

• Contact email

  Andrea.Collins@lstmed.ac.uk

• Sponsor organisation

  Liverpool School of Tropical Medicine

• Duration of Study in the UK

  2 years, 0 months, 0 days

• Research summary

  Streptococcus pneumoniae is the leading cause of morbidity and mortality worldwide, causing community acquired pneumonia (CAP), bacterial meningitis and bacteraemia. Pneumococcal infections cause over 1 million pneumonia deaths per year in children in the developing world and is a major burden of otitis media globally. The Experimental Human Pneumococcal Challenge (EHPC) Model has been developed over ten years in which healthy participants are nasally challenged with live pneumococcal bacteria to determine colonisation rates, immune responses and test pneumococcal vaccines. In order to increase the relevance of the model and its use for vaccine development, we wish to now further develop the EHPC model to include other serotypes of S. pneumoniae. In this study we will establish safe colonisation with SPN 3.

• REC name

  North West - Liverpool Central Research Ethics Committee

• REC reference

  19/NW/0238

• Date of REC Opinion

  23 May 2019

• REC opinion

  Favourable Opinion