EFFORT Study
Research type
Research Study
Full title
Effect of Exercise on Insulin Resistance
IRAS ID
138536
Contact name
Michael I Trenell
Contact email
Sponsor organisation
Alere Inc
Research summary
Does exercise according to current recommendations reduce insulin resistance in subjects at risk for diabetes?
In subjects with insulin resistance (IR), the ability of the cells to respond to the normal actions of insulin is decreased. Hence the cells cannot easily absorb glucose from the blood stream. Over time, IR can lead to high blood glucose (sugar) levels and type 2 diabetes. Both short- and long-term exercise sessions have shown benefits in terms of IR reduction. IR reduction will benefit diabetes prevention. Lifestyle management programs, including exercise, have shown great benefits in the reduction of diabetes development. However, it is not known if exercise according to the current recommendations has an immediate effect on IR after short-term practice. Such an immediate effect would enable continuous feedback to people on an exercise regime. This study will recruit approximately 30 subjects who are insulin resistant and therefore are at a high risk of developing diabetes. Each subject will complete 14 study visits over a period of 3-6 weeks. Subjects will be randomised into an exercise group (current recommendations or a more intensive exercise regime) and will perform 4 exercise sessions over 5 days. The primary aim of the study is to demonstrate that this amount of exercise will have a positive effect on IR. The study is funded by Alere, Inc. and will be conducted at two sites in the UK and one site in the US.REC name
North East - Newcastle & North Tyneside 1 Research Ethics Committee
REC reference
13/NE/0287
Date of REC Opinion
31 Jan 2014
REC opinion
Further Information Favourable Opinion