Efficacy of the HA380 column in critically ill patients-a pilot study
Research type
Research Study
Full title
A Single centre, Open label, Prospective observational, pilot study, comparing the feasibility and efficacy of the HA380 column in critically ill patients requiring Extracorporeal support for acute critical illness with a propensity matched historical cohort. (HACEC Study)
IRAS ID
332858
Contact name
Hakeem Yusuff
Contact email
Sponsor organisation
University Hospitals of Leicester NHS Trust
Duration of Study in the UK
1 years, 6 months, 30 days
Research summary
Patients who are very ill either due to a severe infection, major organ injury, trauma or a major operation may require significant support with devices such as a dialysis machine for the kidneys or Extracorporeal Membrane Oxygenation (ECMO) for the heart and lungs. This is often due to a reaction of the body to the insult which is termed inflammation. We would like to investigate if the use of a device that can remove the agents driving this reaction can lead to a quicker recovery form the illness. The device is a blood filter called HA380 and it would be connected to either the dialysis machine or the ECMO circuit. We will measure this by assessing the time spent on dialysis or ECMO, time spent on the breathing machine, time spent requiring drugs to support their blood pressure and time spent in the intensive care unit.
REC name
Wales REC 4
REC reference
23/WA/0310
Date of REC Opinion
14 Nov 2023
REC opinion
Unfavourable Opinion