Efficacy of combined acetylsalicylic acid & pseudoephedrine on URTI

• Research type

  Research Study

• Full title

  A double blind, placebo-controlled, parallel group study to evaluate the efficacy and safety of acetylsalicylic acid combined with pseudoephedrine, compared with acetylsalicylic acid alone, and pseudoephedrine alone, on symptoms of pain and nasal congestion in patient with symptomatic upper respiratory tract infection.

• IRAS ID

  23480

• Eudract number

  2009-011355-46

• ISRCTN Number

  1

• Research summary

  Viral upper respiratory tract infection (URTI), generally referred to as the common cold anflulike illness, is a multi-symptom disease frequently associated with headache, muscle ache, fever, nasal congestion and sore throat. Acetylsalicylic acid (ASA) known as aspirin can help with pain, fever and inflammation associated with common cold. However, ASA is not expected to provide relief of all of the symptoms of the common cold. One of the most prominent symptoms of common colds is nasal congestion. Pseudoephedrine (PSE) is a compound widely used to relieve nasal congestion associated with common cold. It is reasonable to assume that a combination medicine of ASA and PSE may relieve most of the symptoms of an acute URTI in the treatment of the common cold by treating the pain related and fever symptoms and also nasal congestion.The aim of this study is to investigate the efficacy of combination of oral ASA and PSE, compared with ASA or PSE alone in a placebo(dummy treatment that looks like the real thing) controlled design study.

• REC name

  Wales REC 1

• REC reference

  09/WSE04/37

• Date of REC Opinion

  28 Jul 2009

• REC opinion

  Further Information Favourable Opinion