Efficacy of bone graft material in the placement of dental implants V1
Research type
Research Study
Full title
A clinical trial to determine the relative efficacy of a new bone graft material used in the placement of dental implants compared to a conventional material.
IRAS ID
218869
Contact name
Nicola West
Contact email
Duration of Study in the UK
4 years, 0 months, 6 days
Research summary
Tooth loss is a common problem which can impact on quality of life as it may become more difficult to chew and missing teeth make people self-conscious of their appearance. For these reasons many seek tooth replacement and prefer a fixed tooth replacement (implant) to a denture.
Successful placement of dental implants relies upon there being suitable soft tissues and bone in the region of the missing tooth. If there is not sufficient for the implant to be encased in bone, the area of missing bone is termed a bone defect. An exposed implant surface can affect the predictability of implant success, therefore areas of exposed implant should be encased in bone. Procedures to re-build bone such as grafting (adding bone) may be performed, this allows bone contact with the implant surface to give predictable results. This bone procedure has become common during implant placement to help improve implant predictability and success.
The most common regenerative procedures for the treatment of bony defects are guided tissue regeneration (using a membrane) together with bone grafting. Bone and membranes from non-patient (xenograft) sources are used as they are shown to enhance tissue healing and bone growth while improving the final clinical outcome.
Commonly xenograft material is used, because there is limited bone locally and to avoid donor site morbidity. The use of xenograft material has shown predictable successful outcome for bone augmentation procedures around dental implants. Bio-oss/Bio-gide (Geistlich, UK) is a current system that gives successful and predictable outcomes. However, newer systems are now available which look to improve outcomes, one such system being Symbios (Dentsply, UK). This study will compare the outcomes of implants placed using the two systems to determine their relative efficacies.REC name
South West - Frenchay Research Ethics Committee
REC reference
18/SW/0149
Date of REC Opinion
20 Jul 2018
REC opinion
Further Information Favourable Opinion