Effects of S-555739 on PGD2 induced nasal resistance in adults

• Research type

  Research Study

• Full title

  A randomized, double blind, placebo-controlled, 2-period cross over study to evaluate effects of S-555739 on prostaglandin D2 (PGD2) induced nasal airway resistance in healthy adult volunteers.

• IRAS ID

  11225

• Sponsor organisation

  Shionogi and Co Ltd

• Eudract number

  2008-006787-11

• ISRCTN Number

  n/a

• Research summary

  Allergic rhinitis is the most common of the allergic diseases and has a prevalence of approximately 15% in the UK. Much of the discomfort associated with this condition is due to nasal congestion which is the result of inflammation in the airways. This is mediated by a molecule called Prostaglandin D2 (PGD2) and is found in large amounts in the airways of allergic individuals following an allergic challenge. This project is to test the efficacy of a novel compound S-555739 which acts as a blocking agent on the action of PGD2 by interfering with the receptor that the PGD2 molecule binds to. In preliminary studies this compound has been found to be safe and well tolerated. This study will test the ability of S-555739 to inhibit the increase in nasal airway resistance that results from administering PGD2 to healthy adult volunteers.

• REC name

  South Central - Hampshire B Research Ethics Committee

• REC reference

  08/H0504/206

• Date of REC Opinion

  15 Jan 2009

• REC opinion

  Further Information Favourable Opinion