Effects of intravenous iron therapy on markers of acute kidney injury

• Research type

  Research Study

• Full title

  A prospective randomisd open label study to determine the effects of intravenous iron administration on markers of acute kidney injury in chronic kidney disease

• IRAS ID

  27081

• Contact name

  Sunil Bhandari

• Eudract number

  2010-020452-64

• ISRCTN Number

  n/a

• Research summary

  Chronic kidney disease (CKD) is a worldwide public health problem that affects approximately 6% of the UK adult population and is associated with a high prevalence of cardiovascular disease and high economic cost. Many patients have iron deficiency anaemia. Currently intravenous iron is used regularly in patients with chronic kidney disease to correct anaemia.Debate remains regarding the effects of intravenous Iron on kidney function in patients with chronic kidney disease. When iron is given a small percentage of Iron may be released as "free" iron. This maybe toxic to various kidney cells via processes called oxidative stress and cell toxicity leading to increased leakage of protein form the kidney and potentially causing a deterioration of kidney function which may be progressive or simply transient. This effect may vary depending on the iron preparation used.We therefore want to assess the effects of two preparations of intravenous (IV) iron in a cohort of patients with chronic kidney disease and confirmed iron deficiency who require and are due to receive intravenous iron therapy according to our current guidelines. In particular we will determine whether the two iron preparations (both of which are currently in use in this department) lead to changes in oxidative stress through measurement of known markers in the blood and urine including a few novel markers, one of which is called NGAL. This latter measure may prove useful as a future measure of sub-clinical kidney damage from drug therapy and help guide and monitor the effects of drugs in the kidney.

• REC name

  Yorkshire & The Humber - Leeds East Research Ethics Committee

• REC reference

  10/H1306/40

• Date of REC Opinion

  10 Aug 2010

• REC opinion

  Further Information Favourable Opinion