Effects of Inorganic Nitrite on cardiac and skeletal muscle: CHF
Research type
Research Study
Full title
The Effects of Inorganic Nitrite on cardiac and skeletal muscle: Physiology, Pharmacology and Therapeutic Potential in patients with Chronic Heart Failure
IRAS ID
87162
Contact name
Michael P Frenneaux
Contact email
Eudract number
2012-000788-26
Research summary
Previous studies have shown that interventions modestly increasing blood nitrite, improves muscle function during exercise. Inorganic nitrate in the diet is absorbed into the bloodstream, concentrated in the saliva and reduced by bacteria in the mouth to nitrite, which is then absorbed into the bloodstream. Although evidence indicates that nitrite increases muscle metabolic efficiency, the mechanisms responsible for this dramatic effect remains unknown. The purpose of this 3 month study is to look at the effects of inorganic nitrate supplementation on left ventricular function and exercise capacity.
REC name
Scotland A REC
REC reference
12/SS/0037
Date of REC Opinion
8 May 2012
REC opinion
Further Information Favourable Opinion