Effects of Inorganic Nitrite on cardiac and skeletal muscle: Angina

• Research type

  Research Study

• Full title

  The Effects of Inorganic Nitrite on cardiac and skeletal muscle: Physiology, pharmacology and therapeutic potential in patients suffering from Angina

• IRAS ID

  87080

• Contact name

  Michael P Frenneaux

• Sponsor organisation

  Norfolk and Norwich NHS Foundation Trust

• Eudract number

  2012-000196-17

• Research summary

  Previous studies have shown that interventions modestly increasing plasma nitrite, improves muscle function during exercise. Inorganic nitrate in the diet is absorbed into the bloodstream, concentrated in the saliva and reduced by bacteria in the mouth to nitrite, which is then absorbed into the bloodstream. Although evidence indicates that nitrite increases muscle metabolic efficiency, the mechanisms responsible for this dramatic effect remains unknown. The purpose of this 4 week study is to look at the effects of inorganic nitrate supplementation on the frequency of angina attacks.

• REC name

  Scotland A REC

• REC reference

  12/SS/0018

• Date of REC Opinion

  27 Mar 2012

• REC opinion

  Further Information Favourable Opinion